該基因編碼的蛋白質是一種單鏈dna結合蛋白，與多種dna元素結合，包括c-myc上游的遠上游元素（fuse）。融合結合發生在非編碼鏈上，對未分化細胞中c-myc的調節具有重要意義。該蛋白包含三個結構域，一個雙親螺旋N-末端結構域，一個DNA結合中心結構域，以及一個包含三個富含酪氨酸基序的C-末端反式激活結構域。n-末端結構域被認為抑制了c-末端結構域的活性。這種蛋白質也被認為與RNA結合，并含有3'-5'螺旋酶活性和DNA-DNA和RNA-RNA雙工的體外活性。該基因在惡性腫瘤組織中有異常表達，對神經系統和肺的發育具有重要意義。這種蛋白與病毒rna的結合被認為在一些病毒性疾病中起作用，包括丙型肝炎和手足口病。選擇性剪接導致多個轉錄變體。[由RefSeq提供，2014年12月]
The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]