26S蛋白酶體是一種多催化蛋白酶復合物，由2個復合物、一個20S核和一個19S調節器組成，具有高度有序的結構。20S核由4個28個不相同亞單位的環組成，2個環由7個α亞單位組成，2個環由7個β亞單位組成。19S調節器由一個堿基（包含6個ATPase亞單位和2個非ATPase亞單位）和一個LID（包含10個非ATPase亞單位）組成。蛋白酶體以高濃度分布于真核細胞，并在非溶酶體途徑的ATP/泛素依賴過程中分裂肽。經修飾的蛋白酶體免疫蛋白酶體的一個基本功能是加工I類mhc肽。這個基因編碼19S調節蓋的一個非ATP酶亞單位。在10號和21號染色體上發現了假基因。
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21.