該基因編碼stat誘導的stat抑制因子（ssi）的一個成員，也被稱為細胞因子信號傳導抑制因子（socs）家族。ssi家族成員是細胞因子誘導的細胞因子信號負調控因子。該基因的表達可由一部分細胞因子誘導，包括il2、il3促紅細胞生成素（epo）、csf2/gm-csf和ifn-γ。該基因編碼的蛋白質在細胞因子受體下游發揮作用，并參與負反饋環以減弱細胞因子信號傳導。小鼠的基因敲除研究表明該基因作為ifn-γ作用的調節因子，這是正常的產后生長和生存所必需的。[由RefSeq提供，2008年7月]
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]