camp是一種重要的細胞功能信號分子。camp通過激活camp依賴性蛋白激酶發揮其作用，后者通過不同靶蛋白的磷酸化來傳遞信號。失活激酶全酶是由兩個調節亞基和兩個催化亞基組成的四聚體。camp導致失活的全酶分解成一個二聚體的調控亞基，與四個camp和兩個游離的單體催化亞基結合。四種不同的調節亞基和三種催化亞基已經在人類中被鑒定出來。這個基因編碼一個調節亞單位。這種蛋白被發現是一種組織特異性的滅火劑，可以下調肝癌x成纖維細胞雜種中7個肝基因的表達。這個基因的突變引起卡尼復合體（cnc）。該基因通過基因重排與ret原癌基因融合，形成甲狀腺腫瘤特異性嵌合癌基因ptc2。已發現該蛋白的一個非常規核定位序列（nls），這表明該蛋白作為復制因子c（rfc40）第二亞單位的核轉運蛋白在dna復制中起作用。已觀察到編碼兩種不同亞型的選擇性剪接轉錄變體。[由RefSeq提供，2013年1月]
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013]