前列腺素內過氧化物合酶（PTGS），又稱環加氧酶，是前列腺素生物合成中的關鍵酶，既是一種雙加氧酶又是一種過氧化物酶。PTGS有兩種同工酶：組成型PTGS1和誘導型PTGS2，它們在表達和組織分布的調節上存在差異。這個基因編碼誘導同工酶。它由特定的刺激事件調節，提示它與炎癥和有絲分裂發生相關的前列腺素生物合成有關。
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.