核心結合因子（cbf）是一種與許多增強子和啟動子的核心元素結合的異二聚體轉錄因子。該基因編碼的蛋白質代表CBF的α亞單位，被認為與正常造血的發育有關。涉及這一基因的染色體易位有很好的文獻記載，并與幾種類型的白血病有關。三種編碼不同亞型的轉錄變體已經被發現。
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.