快速床旁(POC)乙肝篩查項目的準確性

一項源于全球數據的薈萃分析結果表明：基于抗原的快速point-of-care（POC）方法來篩查乙型肝炎病毒感染的方法通常是非常準確的，但是基于抗體的篩查的敏感性則有待進一步提高。這一結果在線發表于5月29日美國胃腸病學院的官方雜志《The American journal of gastroenterology》上。

據估計，全球有數千萬人感染乙肝，其中四百萬為急性傳染期病人。在一些低收入和偏遠地區，快速的POC乙肝篩查可能是替代實驗室檢查的重要手段。一項meta分析證實了目前使用的快速POC乙肝篩查手段均具較高準確性，如HBsAg和HBs+eAg檢測。

英文摘要：

OBJECTIVES: Three-hundred fifty million people worldwide are chronically infected with Hepatitis B, with four million acute infections annually. With infection concentrated in hard-to-reach populations and low resource settings, rapid point-of-care (POC) tests offer an efficient screening alternative to laboratory tests. We conducted a meta-analysis to evaluate accuracy of rapid POC tests screening for Hepatitis B.

METHODS: Two reviewers searched four databases, critiqued quality. A hierarchical Bayesian meta-analysis correcting for imperfect reference standards was used. Based on components of the antigen–antibody response, 17 studies were stratified into three subgroups: (i) Hepatitis B surface antigen (HBsAg) tests; (ii) anti-HBsAg tests, and (iii) HBs+eAg tests. Further, we pooled estimates on individual tests with sufficient data.

RESULTS: In subgroup 1, the pooled sensitivity (Sn) was 94.76% (95% credible interval (CrI): 90.08–98.23%) and specificity (Sp) was 99.54% (95% CrI: 99.03–99.95%). The Determine test reported a pooled Sn 98.2% (95% CrI: 94.7, 99.9) and Sp 99.9% (95% CrI: 99.3, 100); in subgroup 2, Sn 93.2% (95% CrI: 85.1, 98.5), Sp 93.1% (95% CrI: 81.9, 99.9); and in subgroup 3, the Binax test showed Sn 95.5% (95% CrI: 88.9, 99.4), Sp 99.8% (95% CrI: 99.3, 100).

CONCLUSIONS: HBsAg tests, including Determine, and the HBs+eAg test, Binax showed high accuracy. Improvements in sensitivity of antibody-based tests will enhance their potential for global first-line screening.

文獻鏈接：

Rapid Point-of-Care First-Line Screening Tests for Hepatitis B Infection: A Meta-Analysis of Diagnostic Accuracy (1980–2010)