氫氣能預防衰老引起的學習能力下降

　　日本這個研究工作已經被接受，盡管研究的設計不是非常出色，但研究的問題是非常引人注目的。該研究采用日本早期篩選的早衰動物SAMP8，研究結果發現，飲用含氫氣水(日本Friendear公司的氫水棒)1月就可以提高動物的抗氧化能力，18周能改善動物的認知能力，保護神經細胞，是否具有延長壽命的作用就值得期待了。

　　實際上，研究抗衰老比較理想的模型可以用更簡單的動物，例如線蟲和果蠅。希望國內研究抗衰老方面的老師關注這個研究。是非常有意思的研究內容和方向。

　　Drinking hydrogen water ameliorated cognitive impairmentin senescence-accelerated mouse

　　Abstract

　　Hydrogen has been reported to have neuron protective effects due to its antioxidant properties, but the effects for cognitive impairment in senescence-related brain alterations and the underlying mechanism have not been characterized. In this study, we investigated the efficacies of drinking hydrogen water for prevention in spatial memory and age-related alteration of the brain using the senescence-accelerated prone mouse 8 (SAMP8), exhibiting early aging syndromes including declining abilities of learning and memory. In the water maze test, aged SAMP8 mice were impaired in place discrimination and in repeated acquisition tasks. However, treatment with hydrogen water for 30 days resulted in prevention of age-related declines in spatial memory processing abilities, associated with increased brain serotonin levels and elevation of serum antioxidant activity. In addition, drinking of hydrogen water for 18 weeks inhibited neurodegeneration in hippocampus, although marked loss of neurons were noted in control aged brain treated with regular water. Our results showed that drinking of hydrogen water on daily basis may present a novel strategy to prevent age-related cognitive disorder.

　　Key words: hydrogen water, senescence, hippocampus, oxidative stress, cognitive disorder