1. Systemic tumor targeting and killing by Sindbis viral vectors
NATURE BIOTECHNOLOGY 22 (1): 70-77, January 2004
本文依據Sindbis病毒對癌細胞表面超量表達的LAMR的識別的機理,以熒光素酶基因分別標記病毒和癌細胞, 觀察標記的病毒在體內對癌細胞的靶向識別和特異性殺傷, 以及標記的癌細胞在體內被病毒侵染后的凋亡和消除。文中還利用標記的病毒檢測到卵巢癌細胞在網膜、膈膜與腸系膜等處的微小轉移灶。
2. Bioluminescence Imaging Reveals Systemic Dissemination of Herpes Simplex Virus Type 1 in the Absence of Interferon Receptors
JOURNAL OF VIROLOGY Vol.77, No.20, p.11082-11093, Oct. 2003
觀察以熒光素酶基因標記的皰疹病毒在不同干擾素受體敲除轉基因小鼠體內的復制和侵染過程, 以此研究一型和二型干擾素受體在病毒侵染過程中的不同作用機理。
3. Optimization of Adenoviral Vectors to Direct Highly Amplified Prostate Specific Expression for Imaging and Gene Therapy
MOLECULAR THERAPY Vol. 8, No. 5, November 2003
本文研究以腺病毒作為基因治療載體的最佳條件。利用兩步激活放大系統和前列腺組織特異性啟動子,觀察作為標記蛋白的熒光素酶在活體動物的前列腺細胞的特異和高效表達。
4. RNA interference in adult mice
NATURE Vol. 418, pp 38, July 4 , 2002
在活體動物體內研究及觀察不同特異性的阻斷RNA對熒光素酶基因和 HCV(丙肝病毒)基因在體內表達的阻斷作用。
5. Bovine Herpes virus Tegument Protein VP22 Enhances Thymidine Kinase/Ganciclovir Suicide Gene Therapy for Neuroblastomas Compared to Herpes Simplex Virus VP22
Journal of Virology, Vol. 78, No. 8, Feb. 2004, p.4224-4233
6. Noninvasive Imaging of Cathionic Lipid-Mediated Delivery of Optical and PET Reporter Genes in Living Mice
Molecular Therapy, Vol. 6, No. 4, October 2002, p. 555
7. Optical Imaging of Transferrin Targeted PEI/DNA Complexes in living subjects
Gene Therapy, 2003, 10, 758-764