細胞凋亡是由核的形態變化所決定的，包括染色質濃縮和核碎裂。該基因編碼一種核蛋白，在caspase-3激活后誘導凋亡染色質濃縮，而不誘導dna斷裂。該蛋白還被證明是一種剪接依賴性多蛋白外顯子連接復合體（EJC）的組成部分，其在mRNAs的剪接連接處沉積，是mRNA前剪接的結果因此，它可能參與與剪接相關的mrna代謝。另外，編碼不同亞型的剪接轉錄變體已經被描述為該基因[由RefSeq提供，2011年10月]
Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]