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  • 發布時間:2022-07-25 10:16 原文鏈接: AKAP8基因突變與藥物因子介紹

    這個基因編碼a激酶錨蛋白家族的一個成員。a激酶錨定蛋白是含有蛋白激酶a(pka)的ri/rii亞單位的結合域并將pka和其他信號分子募集到特定亞細胞位置的支架蛋白。該基因編碼一個核a激酶錨定蛋白,該蛋白與pka的riiα亞單位結合,并可能通過將pka和condensin復合物靶向染色質在有絲分裂過程中參與染色體凝聚。該基因的一個假基因位于9號染色體的短臂上。[由RefSeq提供,2011年5月]
    This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]

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