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  • 發布時間:2022-07-25 10:21 原文鏈接: ALB基因突變與藥物因子介紹

    這個基因編碼人類血液中最豐富的蛋白質。這種蛋白質在調節血漿膠體滲透壓中發揮作用,并作為一種載體蛋白,用于多種內源性分子,包括激素、脂肪酸、代謝物以及外源性藥物。此外,該蛋白具有廣泛的底物特異性和酯酶樣活性。編碼的前蛋白經蛋白質水解處理生成成熟蛋白。從這種蛋白質衍生的肽epi-x4是cxcr4趨化因子受體的內源性抑制劑。[由RefSeq提供,2016年7月]
    This gene encodes the most abundant protein in human blood. This protein functions in the regulation of blood plasma colloid osmotic pressure and acts as a carrier protein for a wide range of endogenous molecules including hormones, fatty acids, and metabolites, as well as exogenous drugs. Additionally, this protein exhibits an esterase-like activity with broad substrate specificity. The encoded preproprotein is proteolytically processed to generate the mature protein. A peptide derived from this protein, EPI-X4, is an endogenous inhibitor of the CXCR4 chemokine receptor. [provided by RefSeq, Jul 2016]

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