BrukerDaltonics在ASMS上推出革命性的超高分辨TOF質譜maXis

2008年6月
丹佛，商業電訊，2008年6月2日，布魯克道爾頓推出maXis?，革命性的新的電噴霧－超高分辨率串聯飛行時間 (UHR-Qq-TOF)質譜儀，新型的maXis 展示了布魯克在設計尖端質譜方面的領先地位，以滿足未來的應用需求，包括：小分子鑒定，代謝組學，定量蛋白質組學，生物標志物的發現及驗證。

maXis 可在寬質量范圍內，達到40,000 ～ 60,000 FWHM的分辨率，MS和MS/MS質量準確度達600～800 ppb，所有的速度可達到每秒采集20張譜圖。在這些無與倫比的性能組合下，maXis 提供：

1）對于高速液相色譜，可在超高質量分辨時達到20 Hz的全譜圖采集速度

2）在寬質量范圍內，在MS和MS/MS模式下均可獲得40,000 ～ 60,000 FWHM的分辨率

3）寬m/z質量范圍

4）新型的IonCooler?技術，在寬的m/z范圍內，可獲得出色的MS/MS靈敏度

5）高達5個數量級的動態范圍，適用于復雜混合物的痕量檢測

6）在MS和MS/MS模式下，均可獲得亞ppm級的質量準確度，用于高確定性的鑒定）

7）用于（目標物）發現應用的超高質譜靈敏度

8）SmartFormula? 三維高確定性的分子測定，可計算化學式至1,000 Da

“現在，在寬質量范圍內獲得超高分辨的質譜，最終會兼容超高效液相色譜。” Ian Sanders，布魯克道爾頓的執行副總裁說，“我們的新maXis的確代表了串聯質譜技術的主要進步，對于精確質量測定，寬質量范圍內的超高分辨率，在高速下獲得MS和MS/MS的高靈敏度，maXis提供了一個出色的解決方案，能利用現代快速液相色譜或快速毛細管電泳分離的所有優點。”

Richard Joyce博士，輝瑞Pfizer公司的結構鑒定科學家評論說：“ 大大省時地解決現實生活中的鑒定問題對我們至關重要：我們在maXis性能的水平上，利用SmartFormula 3D的合作開發，達到了“一桿式分子式機器(one-shot Molecular Formula Machine)”的目標。”

在周日（6月1日）的布魯克道爾頓的用戶會上，一位著名的研究者將詳細介紹他的小組使用布魯克道爾頓的儀器，包括maXia，進行的一系列創新的應用。周一會有一個香檳招待會，介紹新推出的maXis。

英文原文：
Bruker Daltonics Introduces maXis?, a Revolutionary New Ultra-High Resolution TOF Mass Spectrometer at ASMS Conference
. June 2008
 

DENVER--(BUSINESS WIRE)--June 2, 2008--At ASMS 2008, Bruker Daltonics today announced the maXis?, a revolutionary new Electrospray Ultra-High Resolution tandem TOF (UHR-Qq-TOF) mass spectrometer. The novel maXis demonstrates Bruker's leadership in the design of cutting-edge mass spectrometers to meet future requirements in applications including small molecule identification, metabolomics, quantitative proteomics, as well as biomarker discovery and validation.

The maXis is unique in offering simultaneous no-compromise ultra-high resolution of 40,000 - 60,000 FWHM over a broad mass range, MS and MS/MS mass accuracy typically between 600 and 800 ppb, and all at speeds of up to 20 full spectra per second. With its unprecedented performance combination, the maXis offers:

-- 20 Hz full spectra acquisition at ultra-high mass resolution for high-speed liquid chromatography

-- 40,000 - 60,000 resolution in both MS and MS/MS mode over a broad mass range

-- excellent high m/z mass range

-- novel IonCooler? technology delivers excellent MS/MS sensitivity over a broad m/z range

-- high dynamic range of 5 orders of magnitude for trace detection in complex mixtures

-- sub-ppm mass accuracy in both MS and MS/MS mode for high confidence IDs

-- uncompromised MS sensitivity for discovery applications

-- SmartFormula? 3D unambiguous determination of molecular sum formulae for molecules up to 1 kDalton;

 "Now ultra-high resolution mass spectrometry over broad mass ranges is finally compatible with ultra performance liquid chromatography," explained Bruker Daltonics Executive Vice President Dr. Ian Sanders. "Our new maXis indeed represents a major step forward in tandem mass spectrometry, offering a no-compromise solution for exceptional accurate mass, ultra-high resolution over a broad mass range and high sensitivity MS and MS/MS analysis at a speed able to take full advantage of modern, fast liquid chromatography or fast capillary electrophoresis separations."

Dr. Richard Joyce, Structural Elucidation Scientist at Pfizer (UK), commented: "It is vital to us to solve real-life identification problems in a dramatically reduced time: our joint development of SmartFormula 3D applied at maXis performance levels meets our goal of a one-shot Molecular Formula Machine."

At the Bruker Daltonics Users Forum on Sunday, June 1st, a prestigious panel of researchers made presentations detailing a series of innovative applications utilizing various Bruker Daltonics instruments, including the maXis. On Monday, June 2nd, at 6:30 p.m. there will also be a special champagne reception in the Bruker Hospitality Suite at the Sheraton Denver Hotel for the introduction of the maxis (no registration required).

For more information on the ASMS conference, please visit www.asms.org

For more information about Bruker Daltonics and Bruker Corporation (NASDAQ: BRKR), please visit www.bdal.com and www.bruker.com.

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