該基因是來自鈣黏蛋白超家族的ii型經典型鈣黏蛋白，是位于18號染色體簇中的三個類鈣黏蛋白7基因之一。編碼的膜蛋白是一種鈣依賴性細胞粘附糖蛋白，由5個細胞外鈣黏蛋白重復序列、一個跨膜區和一個高度保守的胞質尾組成。II型（非典型）鈣粘蛋白的定義是基于其缺乏一個特定于I型鈣粘蛋白的HAV細胞粘附識別序列。由于細胞內粘附障礙是腫瘤細胞侵襲和轉移的先決條件，鈣粘蛋白被認為是腫瘤抑制基因的主要候選基因。[由RefSeq提供，2008年7月]
This gene is a type II classical cadherin from the cadherin superfamily and one of three cadherin 7-like genes located in a cluster on chromosome 18. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Since disturbance of intracellular adhesion is a prerequisite for invasion and metastasis of tumor cells, cadherins are considered prime candidates for tumor suppressor genes. [provided by RefSeq, Jul 2008]