該基因編碼一個I型細胞因子受體家族成員。編碼蛋白是胸腺基質淋巴生成素（TSLP）的受體。與白細胞介素7受體（IL7R）一起，編碼蛋白和tslp激活Stat3、Stat5和Jak2途徑，這些途徑控制細胞增殖和造血系統發育等過程。該基因與14號染色體上的免疫球蛋白重鏈基因（igh）或同一X或Y染色體上的p2y嘌呤核蛋白8基因（p2ry8）的重排與B祖細胞急性淋巴細胞白血病（all）和唐氏綜合征（all）有關。另外，還發現了該基因的剪接轉錄變體。
This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene.