該基因編碼的蛋白是CXC趨化因子家族的一員，是炎癥反應的主要介質編碼的蛋白質主要由中性粒細胞分泌，在中性粒細胞中，它通過引導中性粒細胞到達感染部位起到趨化因子的作用。這種趨化因子也是一種有效的血管生成因子。該基因被認為在毛細支氣管炎（一種由病毒感染引起的常見呼吸道疾病）的發病機制中起作用。該基因和CXC趨化因子基因家族的其他成員在4q染色體區域形成一個基因簇。[由RefSeq提供，2017年8月]
The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, Aug 2017]