該基因編碼凝血因子iii，它是一種細胞表面糖蛋白。該因子使細胞啟動凝血級聯反應，并作為凝血因子VII的高親和力受體發揮作用由此產生的復合物提供了一種催化事件，該催化事件負責通過特定的限制性蛋白水解引發凝血蛋白酶級聯。與這些蛋白酶級聯的其他輔因子不同，這些輔因子作為非功能性前體循環，當在細胞表面表達時，這個因子是一個有效的引發劑，具有完全的功能。該因子有3個不同的結構域：細胞外、跨膜和細胞質。這種蛋白質是凝血途徑中唯一一種尚未被描述為先天性缺陷的蛋白質交替剪接導致多個轉錄變體。[由RefSeq提供，2010年5月]
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]