該基因編碼udp-galnac家族的一個成員：多肽n-乙酰半乳糖胺基轉移酶，在o-連接蛋白糖基化的初始步驟中催化n-乙酰半乳糖胺（galnac）從udp-galnac轉移到多肽受體上的絲氨酸或蘇氨酸殘基。這個基因的突變與結直腸癌易感性的增加有關。
This gene encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Mutations in this gene are associated with an increased susceptibility to colorectal cancer.[provided by RefSeq, Mar 2011]