組蛋白是構成真核生物染色體纖維核小體結構的基本核蛋白四個核心組蛋白（H2A、H2B、H3和H4）中的每一個分子形成一個八聚體，其中大約146 bp的DNA被包裹在被稱為核小體的重復單元中。連接組蛋白H1在核小體之間與連接DNA相互作用，在染色質壓縮成高階結構中發揮作用該基因編碼組蛋白H2A家族成員中一個與復制無關的組蛋白，并通過保守的莖環終止基序和polyA加合基序產生兩個轉錄本[由RefSeq提供，2015年10月]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Oct 2015]