組蛋白是構成真核生物染色體纖維核小體結構的基本核蛋白該結構由包裹在核小體周圍的約146 bp的DNA組成，由四個核心組蛋白（H2A、H2B、H3和H4）中的每一個組成的八聚體組成。染色質纖維通過連接組蛋白h1與核小體之間的dna相互作用進一步緊密，形成高階染色質結構。該基因無內含子，編碼一個復制依賴性組蛋白，是組蛋白h3家族的成員。這個基因的轉錄本沒有polya尾；相反，它們包含一個回文終止元素。這個基因在1號染色體上的組蛋白簇中發現。這個基因是群中四個重復的組蛋白基因之一；這個記錄代表端粒拷貝。[由RefSeq提供，2015年8月]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, Aug 2015]