組蛋白是構成真核生物染色體纖維核小體結構的基本核蛋白該結構由包裹在核小體周圍的約146 bp的DNA組成，由四個核心組蛋白（H2A、H2B、H3和H4）中的每一個組成的八聚體組成。染色質纖維通過連接組蛋白h1與核小體之間的dna相互作用進一步緊密，形成高階染色質結構。該基因無內含子，編碼一個復制依賴性組蛋白，是組蛋白h3家族的成員。這個基因的轉錄本沒有polya尾；相反，它們包含一個回文終止元素。該基因存在于6p22-p21.3號染色體上的大組蛋白基因簇中。[由RefSeq提供，2015年8月]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]