該基因編碼的蛋白質是一種轉錄調節因子和腫瘤抑制因子，是參與先天性和獲得性免疫應答的基因激活因子。編碼的蛋白質激活參與機體對病毒和細菌反應的基因轉錄，在細胞增殖、凋亡、免疫反應和DNA損傷反應中發揮作用這種蛋白質抑制其他幾個基因的轉錄。作為一種抑癌劑，它既抑制腫瘤細胞的生長，又刺激對腫瘤細胞的免疫反應。這個基因的缺陷與胃癌、骨髓白血病和肺癌有關[由RefSeq提供，2017年8月]
The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017]