該基因編碼低密度脂蛋白（ldl）受體基因家族的一個成員。ldl受體是參與受體介導的脂蛋白和蛋白配體內吞的跨膜細胞表面蛋白。該基因編碼的蛋白質作為wnt的受體或與frizzled一起作為wnt的共同受體，從而傳遞典型的wnt/β-catenin信號級聯。通過與wnt/beta-catenin信號級聯的相互作用，該基因在調節細胞分化、增殖、遷移和多種癌癥類型的發展中發揮作用。該蛋白經歷伽瑪分泌酶依賴的RIP（調節膜內蛋白水解）處理，但切割位點的精確位置尚未確定。[由Refseq提供，2009年12月]
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]