該基因編碼的蛋白與myd88結合在toll樣受體4（tlr4）的胞漿末端，從而激活核因子kappa b信號傳導。泛素樣蛋白fat10阻止編碼蛋白與tlr4的相互作用，從而使核因子kappa b信號途徑失活。此外，這種蛋白可以通過將caspase-1抑制劑flightless-i招募到炎癥復合物中來下調nlrp3炎癥。[由RefSeq提供，2017年1月]
The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]