DNA的雙鏈斷裂是由遺傳毒性應激引起的，是DNA損傷最嚴重的損傷之一。該基因編碼非同源末端連接途徑所必需的dna修復因子，該因子優先介導雙鏈斷裂的修復。這種基因的突變會導致不同類型的嚴重聯合免疫缺陷疾病。[由RefSeq提供，2008年7月]
Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders. [provided by RefSeq, Jul 2008]