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  • 發布時間:2022-08-02 11:25 原文鏈接: PABPC1基因突變與藥物因子介紹

    這個基因編碼一種多聚(a)結合蛋白。蛋白質在細胞核和細胞質之間穿梭,通過rna識別基序與真核信使rna的3'聚(a)尾結合。該蛋白與poly(A)的結合促進了核糖體的募集和翻譯起始;poly(A)縮短也是mRNA衰變的第一步該基因是一個小基因家族的一部分,包括三個蛋白質編碼基因和幾個假基因
    This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]

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