3'，5'-環核苷酸camp和cgmp在多種信號轉導途徑中起第二信使的作用。3'，5'-環核苷酸磷酸二酯酶（pdes）催化camp和cgmp水解為相應的5'-單磷酸，并提供下調camp和cgmp信號的機制。這個基因編碼pde蛋白超家族的一個成員。該基因突變是庫欣病和腎上腺皮質增生的原因。已發現該基因編碼不同亞型的多個轉錄變體。
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.