這個基因編碼一個sestrin家族的成員SSTRIN是由p53腫瘤抑制蛋白誘導的，并在細胞對DNA損傷和氧化應激的反應中起作用。編碼蛋白通過激活amp激活的蛋白激酶介導p53對細胞生長的抑制，從而抑制雷帕霉素蛋白的哺乳動物靶點。編碼過氧化過氧化還原酶的蛋白質也在抗氧化防御中起著關鍵作用，該基因的表達是輻射暴露的潛在標志物。另外，已經觀察到該基因編碼多個亞型的剪接轉錄變體。
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.