zeta肉瘤聚糖基因的大小超過465kb，定位于8p22。這種蛋白質是肉聚糖復合物的一部分，由6種蛋白質組成肉瘤聚糖均為N-糖基化跨膜蛋白，具有短的細胞內結構域、單一的跨膜結構域和大的胞外結構域，其中含有羧基末端簇和一些保守的半胱氨酸殘基肌甘聚糖復合物是肌營養不良相關糖蛋白復合物（dgc）的一部分，它連接細胞內骨架和細胞外基質。
The zeta-sarcoglycan gene measures over 465 kb and localizes to 8p22. This protein is part of the sarcoglycan complex, a group of 6 proteins. The sarcoglycans are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a carboxyl-terminal cluster with several conserved cysteine residues. The sarcoglycan complex is part of the dystrophin-associated glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extra-cellular matrix.