該基因編碼絲氨酸/蘇氨酸蛋白激酶，在細胞應激反應中起重要作用。這種激酶激活某些鉀、鈉和氯通道，提示參與調節細胞存活、神經元興奮性和腎鈉排泄等過程。這種基因的高水平表達可能導致高血壓和糖尿病腎病等疾病。幾個選擇性剪接的轉錄變體編碼不同的亞型已經注意到這個基因。
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.