這個基因編碼的蛋白質是基因組穩定性的重要調節因子該蛋白代表SLX1-SLX4結構特異性核酸內切酶的催化亞單位，它可以解析修復和重組過程中形成的DNA二級結構由于節段性重復，該基因的兩個相同拷貝位于16號染色體的p臂上；該記錄代表更多的著絲粒拷貝。選擇性剪接導致多個轉錄變體該基因與下游SULT1A3（硫轉移酶家族，胞質，1A，苯酚偏好，成員3）基因之間也存在讀寫轉錄[由RefSeq提供，2010年11月]
This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more centromeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A3 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3) gene. [provided by RefSeq, Nov 2010]