該基因編碼的蛋白是toll樣受體（toll-like receptor，tlr）家族的一員，在病原體識別和天然免疫激活中起著重要作用。從果蠅到人類，tlr高度保守，結構和功能相似。它們識別病原體相關的分子模式，在傳染源上表達，并介導細胞因子的產生，這些細胞因子是發展有效免疫所必需的。不同的tlr表現出不同的表達模式。該受體與大多數革蘭氏陰性菌脂多糖（lps）誘導的信號轉導事件有關。該基因突變與lps反應性的差異有關。已發現該基因編碼不同亞型的多個轉錄變體。[由RefSeq提供，2012年1月]
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]