通過泛素-蛋白酶體系統（ups）調節真核生物中錯誤折疊、損傷或短命蛋白質的降解。UPS系統的一個組成部分是靶蛋白的泛素化和含Ub蛋白的共價連接形成聚合鏈，將其標記為26S蛋白酶體介導的降解靶蛋白質泛素化是由一系列酶介導的，這些酶包括E1（泛素激活）、E2（泛素結合）和E3（泛素連接酶）這個基因編碼E2酶家族的一個成員。該酶的底物包括腫瘤抑制蛋白p53和過氧化物酶體生物發生因子5（pEX5）。選擇性剪接導致該基因的多個轉錄變體。
Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene.