該基因編碼一種高度保守的冷休克蛋白，具有廣泛的核酸結合特性。編碼蛋白作為一種dna和rna結合蛋白，參與多種細胞過程，包括轉錄和翻譯調控、mrna前剪接、dna修復和mrna包裝。該蛋白也是信使核糖核蛋白（mrnp）復合物的組成部分，可能在microrna加工中起作用。這種蛋白可以通過非經典途徑分泌，并作為細胞外有絲分裂原發揮作用。該基因的異常表達與許多組織中的癌癥增殖有關。該基因可能是某些癌癥預后差和耐藥的一個預后標志。交替剪接導致多個轉錄變體。該基因的假基因存在于多條染色體上。[由RefSeq提供，2015年9月]
This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015]