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  • 發布時間:2022-07-27 07:35 原文鏈接: GABRP基因突變與藥物因子介紹

    γ-氨基丁酸(GABA)A受體是介導中樞神經系統最快抑制性突觸傳遞的多亞單位氯通道該基因編碼的亞單位在包括子宮和卵巢在內的一些非神經組織中表達。該亞單位可以與已知的GABA A受體亞單位結合,并且該亞單位的存在改變了重組受體對如孕烯醇酮等調節劑的敏感性另外,已經發現該基因編碼不同亞型的剪接轉錄變體[由RefSeq提供,2014年5月]
    The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

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