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Her2 or ERBB2 belongs to a class of proteins having high homology with epidermal growth factor receptor (EGFR or ERBB1). It encodes a protein with the molecular weight of 185 KDa. Unlike other members of EGFR family, no ligand for Her2 has been found and it usually associates with members of ERBB1 family to form functional heterodimers. It has been shown that it can form dimers with ERBB (EGFR), ERBB3 and ERBB4 as we......閱讀全文
The signal transduction cascade responsible for sensing light in vertebrates is one of the best studied signal transduction processes, and is initiate
Significant progress has been made towards delineation of the intrinsic molecular processes that regulate B lymphocyte immune function. Recent observa
ABSTRACTFibroblast growth factor (FGF) signaling plays a signifigant role in embryonic development. Particularyl, FGFs are implicated in mediating epi
2.2 Interaction mating - large scaleWith a few modifications, the procedure described above can be used to test for interactions between a single prey
Axons extend significant distances to innervate target tissues. At the site of innervation, target tissues release neurotrophins including NGF, BDNF a
The IL-2 receptor is a key component of immune signaling and is required for the activation, proliferation, and survival of T cells. This receptor is
來自美國卡內基研究院（Carnegie Institution），中科院植物研究所光合作用與環境分子生理學重點實驗室（Key Laboratory of Photosynthesis and Environmental Molecular Physiology），加州大學舊金山分校，河北師范大學，斯
The hepatocyte growth factor receptor, also called c-Met, is activated by HGF and stimulates proliferation of hepatocytes and other cell types. Mutate
While transcriptional regulation is often viewed as the most prevalent way extracellular signals to regulate gene expression, post-transcriptional reg
Exposure to divalent cadmium ions (Cd2+) is a known cancer risk factor, but the molecular mechanisms responsible for the inappropriate induction of ce
CXCR4 is a chemokine receptor in the GPCR gene family, and is expressed by cells in the immune system and the central nervous system. In response to b
41. Schmidt O, Theopold U, Strand M: Innate immunity and its evasion and suppression by hymenopteran endoparasitoids. BioEssays 2001, 23(4):344–35
Nitric oxide (NO) has a number of important physiological actions in the cardiovascular system. In the heart, NO plays role in keeping the vessels pat
The neuregulins comprise a subfamily of at least four epidermal growth factor (EGF)-like growth factors that influence a variety of cellular events, i
Endothelial cells (EC) form a multifunctional signal-transducing surface that performs different tasks dependent on its localization in the vessel tre
Comparative assessment of glycosylation of recombinant human FSH and highly purified FSHHong Wang, Xi Chen, Xiaoxi Zhang, Wei Zhang, Yan Li, Hongrui Y
Site-specific characterization of N-glycansFor intact N-glycopeptide analysis, chymotryptic digests of both hFSHs were subjected under UPLC equipped
Phospholipase C (PLC) d1 is a member of the PLC family that produces two second messengers, diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3)
The innate immune response responds in a general manner to factors present in invading pathogens. Bacterial factors such as lipopolysaccharides (LPS,
細胞凋亡是一種在基因控制下的細胞主動死亡過程，通常表現為核濃縮，起皺，膜發泡以及 DNA 片段化。WB 是研究細胞凋亡機理的基本方法之一，但是 WB 也不是誰都能做成功的，因為有可能你的第一步就做錯了！用 WB 做細胞凋亡研究樣品制備是第一步，樣品制備方法至關重要否則會得到錯誤的結果和結論。樣品制備
Interaction of T cell receptor with specific antigen in the context of MHC II activates a signal transduction pathway that leads to T cell activation.
Thrombin is an extracellular protease that is involved in the clotting of blood and inflammation through its action on platelets and endothelial cells
The phosphorylation of myosin affects its role in smooth muscle contraction, platelet formation and possibly other processes. Phosphorylation by myosi
The activation of T cells requires a co-stimulatory signal with T cell receptor activation, provided in many cases by activation of CD28 in resting T
NK (natural killer) cells are lymphocytes distinct from B and T cells that induce perforin-mediated lysis of tumor cells and virus-infected cells. NK
Campus & Enterprise Facility NetworksMillimetre Wave Wireless Networks are very suited to both long term and short term solutions where organi
The ever evolving mitogen-activated protein kinase (MAP kinase) pathways consist of four major groupings and numerous related proteins which constitut
眾所周知，2017 諾貝爾生理或醫學獎頒發給了三位美國遺傳學家杰弗里·霍爾（Jeffrey C. Hall）、邁克爾·羅斯巴什（Michael Rosbash），以及邁克爾·楊（Michael W. Young），以表彰他們在發現果蠅生物節律分子機制方面的貢獻。而在此前，醫學界真正將生物節律——
The epidermis, which provides a protective barrier that undergoes a constant renewal, is a multi-layered tissue with the proliferating cells located i
生物通報道：來自中科院上海生命科學院/上海交通大學醫學院健康科學研究所，同濟大學醫學院的研究人員發表文章，證明了一種腸道細菌中的重要蛋白：Tir能與宿主細胞相互作用，抑制宿主細胞的免疫作用，從而造成病原感染。這項研究揭示了一種前所未有天然免疫應答逃逸機制，相關成果公布在Nature