WIKI資訊
Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1a) is a tissue-specific coactivator that enhances the activity of many nuclear receptors and coordinates transcriptional programs important for energy metabolism and energy homeostasis. Inappropriate increases in PGC-1a activity have been linked to a number of pathological conditions including heart failure and diabetes. PGC-1a is highly expre......閱讀全文
MicroRNA Expression Profiling by Bead Array Technology in Human Tumor Cell Lines Treated with Interferon-Alpha-2aMicroRNAs are positive and negative r
Eukaryotic cells take up constituents of the extra-cellular environment and regulate the cell-surface level of membrane proteins via a recycling syste
2018年9月26日，歐盟委員會發布法規（EU）2018/1292，根據歐洲議會和理事會法規（EU）No 528/2012，批準苯醚氰菊酯（cyphenothrin）作為活性物質用于18類產品的生物農藥產品，活性物質的最低純度為92%w/w（總異構體），批準日期為2020年2月1日，到期日為2
Bead-array-based microRNA detection technology, including the bio-statistic analysis, is currently not well established or widely used and we have app
來自美國卡內基研究院（Carnegie Institution），中科院植物研究所光合作用與環境分子生理學重點實驗室（Key Laboratory of Photosynthesis and Environmental Molecular Physiology），加州大學舊金山分校，河北師范大學，斯
The eicosanoids are a family of lipophilic hormones derived from the twenty carbon fatty acid arachidonic acid. Although they are diverse in structure
The calcium/calmodulin-dependent kinases (CaMKs) are involved in a large number of cellular responses induced by hormones, neurotransmitters and other
While transcriptional regulation is often viewed as the most prevalent way extracellular signals to regulate gene expression, post-transcriptional reg
Telomeres, which define the ends of chromosomes, consist of short, tandemly repeated DNA sequences loosely conserved in eukaryotes. Telomerase is a ri
Packaging of DNA into chromatin allows the cell to store its genetic information efficiently and has an important role in regulating gene expression.
Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine
Four different members of the Sprouty protein family block the cellular proliferation and differentiation induced by several different growth factors,
The chromatin packaging of the genome is dynamic, changing with the cell cycle and with transcriptional regulation. During mitosis, chromatin is conde
Andreas D.BaxevanisGenome Technology BranchNational Human Genome Research InstitudeNational Institutes of HealthBethesda.Maryland 在尋找基因和致力于發現新蛋白的
Phospholipase C (PLC) d1 is a member of the PLC family that produces two second messengers, diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3)
Hypoxic stress, like DNA damage, induces p53 protein accumulation and p53-dependent apoptosis in oncogenically transformed cells. Unlike DNA damage, h
據歐盟官方公報消息，歐盟批準苯甲酸（benzoic acid）、甲酸鈣（calcium formate）和富馬酸（ fumaric acid）作為肉雞和蛋雞的飼料添加劑。 2018年7月12日，歐盟委員會發布法規 （EU） 2018/982，根據第1831/2003號條例（EC）批準苯甲酸
據歐盟官方公報消息，2018年12月12日，歐盟委員會發布公告Commission Implementing Regulation （EU）2018/1957，該公告決定修訂甲基鹽霉素和尼卡巴嗪制劑（the preparation of narasin and nicarbazin）的授權條款以
The binding of ?-arrestins to agonist-occupied GPCRs triggers the assembly of a MAP kinase activation complex using ?-arrestin as a scaffold, with sub
Sterol-regulatory element binding proteins (SREBPs) play a key role in transcriptional regulation of cholesterol metabolism in response to cholesterol
組蛋白去乙酰化酶（HDAC, histone deacetylase）是癌癥藥物研發領域的熱點。在人類中存在18種不同的HDAC，可以進一步細分為4類：I類HDAC（HDAC1、2、3和8）主要存在于細胞核中，主要功能是給組蛋白脫乙酰基。II類HDAC進一步分為：IIa類（HDAC4、5、7和9
The binding of ?-arrestins to agonist-occupied GPCRs coincides with the recruitment of Src family tyrosine kinases, including c-Src, Hck and c-Fgr (Sr
據歐盟官方公報消息，6月10日歐盟委員會發布（EU） 2017/983條例，修訂（EC） No 396/2005條例附件III與V中關于三環唑在多種商品中的殘留限量。 新條例自發布后第20天起生效。按照新限量，部分果蔬、堅果、塊根、塊莖類蔬菜中三環唑的限量為0.01ppm。 針對除印度
近二十年來，科學家開始逐漸認識到DNA中的遺傳密碼只代表了生命藍圖中的一部分信息。遺傳信息還來自于DNA結構上的特殊化學標簽模式，這些表觀遺傳學標簽決定了DNA包裝的緊密程度以及特定基因的開關。 隨著越來越多的表觀遺傳學標簽被發現，
據歐盟網站消息，4月6日歐盟委員會發布EU 2017/644號條例，制定歐盟制定食品中二惡英、二惡英類多氯聯苯（PCBs）和非二惡英類多氯聯苯的取樣與分析方法，廢止EU 589/2014條例。 EU 589/2014條例由EU 2017/644號條例的附件I-IV替代，附件I列出定義和縮寫
據歐盟網站消息，4月6日歐盟委員會發布EU 2017/623、EU 2017/624號委員會條例，修訂（EC）No 396/2005中關于12種農藥殘留限量的標準附錄II和附錄III。 這12種農藥包括：滅螨醌（acequinocyl）、雙甲脒（amitraz）、蠅毒磷（coumaphos
2.2 Interaction mating - large scaleWith a few modifications, the procedure described above can be used to test for interactions between a single prey
AbstractPrevious studies by Stachel and colleagues indicate that lithium chloride induction of post-midblastular Brachydanio rerio embryos r
Metabolic biotinylation of mammalian cell receptors for imagingBakhos A. Tannous , btannous@hms.harvard.edu, Massachusetts General Hospital and Harvar
生物分子發表的代表性文獻 QTRAP：同時具有三重四極桿和線性離子阱性能的獨一無二的LC/MS/MS系統 QTRAP系統最早在ASMS 2002上，作為第一臺商用的線性離子阱發布，是世界上唯一的線性離子阱和三重四極桿的復合