SignalingofHepatocyteGrowthFactorReceptor
The hepatocyte growth factor receptor, also called c-Met, is activated by HGF and stimulates proliferation of hepatocytes and other cell types. Mutated forms of the HGF receptor are associated with oncogenesis and metastasis, making the HGF receptor a potential therapeutic target for cancer drugs. Changes in cell motility, cell shape, adhesion, resistance to apoptosis, and anchorage independent growth all contribute ......閱讀全文
Signaling－of－Hepatocyte－Growth－Factor－Receptor
The hepatocyte growth factor receptor, also called c-Met, is activated by HGF and stimulates proliferation of hepatocytes and other cell types. Mutate
Nerve－growth－factor－pathway－(NGF)
Nerve growth factor (NGF) is one of a family of neurotrophins that induce the survival and proliferation of neurons. In cell culture NGF induces the f
Growth－Hormone－Signaling－Pathway
Growth hormone plays a major role in regulating growth during childhood and adolescence and also regulates metabolism. Defects in growth hormone signa
Trka－Receptor－Signaling－Pathway
Nerve growth factor (NGF) is a neurotrophic factor that stimulates neuronal survival and growth through TrkA, a member of the trk family of tyrosine k
T－Cell－Receptor－Signaling－Pathway
The T Cell Receptor plays a key role in the immune system. The specificity of the receptor is governed by the binding site formed from the mature alph
Msp/Ron－Receptor－Signaling－Pathway
MSP, macrophage-stimulating protein, acts through the transmembrane receptor kinase RON (Stk in mice) to play a role in inflammation and the response
Fc－Epsilon－Receptor－I－Signaling－in－Mast－Cells
The Fc Epsilon Receptor 1 signaling pathway in mast cells uses multiple core signal path to achieve its necessary ends. Through the BTK protein and PK
IL22－Soluble－Receptor－Signaling－Pathway
IL-22 is an inflammatory cytokine related to IL-10 that is produced by T cells and that induces a response in cells through a heterodimeric cell surfa
Growing－Cells－in－Geltrex?－Reduced－Growth－Factor－Basement－Membrane－Matrix
實驗概要Basement ?membranes are continuous sheets of specialized extracellular matrix ?that form an interface between endothelial, epithelial, muscle, or
酪氨酸激酶的受體型
受體酪氨酸激酶（receptor protein tyrosine kinases，RPTKs）的胞外區是結合配體結構域，配體是可溶性或膜結合的多肽或蛋白類激素，包括胰島素和多種生長因子。胞內段是酪氨酸蛋白激酶的催化部位，并具有自磷酸化位點。 配體（如EGF）在胞外與受體結合并引起構象變化，導
TGFβ（transforming－growth－factorβ）的功能和作用機制
TGFβ（transforming growth factor-β）是由多種動物細胞合成與分泌、以非活性形式儲存在細胞胞外基質中結構相關的信號分子超家族，TGFβ超家族是一類作用廣泛、具有多種功能的生長因子，對不同的細胞類型或處于不同狀態的同一細胞會引起不同的反應。TGFβ通過具有絲氨酸/蘇氨酸激酶
TGFβ（transforming－growth－factorβ）的功能和作用機制
TGFβ（transforming growth factor-β）是由多種動物細胞合成與分泌、以非活性形式儲存在細胞胞外基質中結構相關的信號分子超家族，TGFβ超家族是一類作用廣泛、具有多種功能的生長因子，對不同的細胞類型或處于不同狀態的同一細胞會引起不同的反應。TGFβ通過具有絲氨酸/蘇氨酸激酶
IGF1－Signaling－Pathway
Insulin like growth factor 1 (IGF-1) and its receptor (IGF-1R) provide a potent proliferative signaling system that stimulates growth in many differen
Sprouty－regulation－of－tyrosine－kinase－signals
Four different members of the Sprouty protein family block the cellular proliferation and differentiation induced by several different growth factors,
CBL－mediated－ligandinduced－downregulation－of－EGF－receptors
As with many cell-surface receptors, activation of the EGF receptor can result in receptor internalization through receptor-mediated endocytosis, dese
Neuroregulin－receptor－degredation－protein1－Controls－ErbB3－receptor
The neuregulins comprise a subfamily of at least four epidermal growth factor (EGF)-like growth factors that influence a variety of cellular events, i
與胃癌相關的SPRY2基因編碼功能描述
這個基因編碼一種屬于芽科的蛋白質。編碼蛋白含有一個羧基末端富含半胱氨酸的結構域，對受體酪氨酸激酶信號蛋白的抑制活性至關重要，并且對于生長因子刺激的蛋白質向膜皺褶的易位是必需的。在原發性真皮內皮細胞中，該基因對成纖維細胞生長因子2的反應是短暫上調的。該蛋白間接參與了對成纖維細胞生長因子2信號傳導的非細
與肺癌相關的SPRY2基因編碼功能描述
這個基因編碼一種屬于芽科的蛋白質。編碼蛋白含有一個羧基末端富含半胱氨酸的結構域，對受體酪氨酸激酶信號蛋白的抑制活性至關重要，并且對于生長因子刺激的蛋白質向膜皺褶的易位是必需的。在原發性真皮內皮細胞中，該基因對成纖維細胞生長因子2的反應是短暫上調的。該蛋白間接參與了對成纖維細胞生長因子2信號傳導的非細
SPRY2基因編碼的功能和結構描述
這個基因編碼一種屬于芽科的蛋白質。編碼蛋白含有一個羧基末端富含半胱氨酸的結構域，對受體酪氨酸激酶信號蛋白的抑制活性至關重要，并且對于生長因子刺激的蛋白質向膜皺褶的易位是必需的。在原發性真皮內皮細胞中，該基因對成纖維細胞生長因子2的反應是短暫上調的。該蛋白間接參與了對成纖維細胞生長因子2信號傳導的非細
SPRY2基因突變因子與藥物介紹
這個基因編碼一種屬于芽科的蛋白質。編碼蛋白含有一個羧基末端富含半胱氨酸的結構域，對受體酪氨酸激酶信號蛋白的抑制活性至關重要，并且對于生長因子刺激的蛋白質向膜皺褶的易位是必需的。在原發性真皮內皮細胞中，該基因對成纖維細胞生長因子2的反應是短暫上調的。該蛋白間接參與了對成纖維細胞生長因子2信號傳導的非細
GPB7基因編碼功能及結構描述
這個基因的產物屬于一個小的轉接器蛋白家族，已知它與許多受體酪氨酸激酶和信號分子相互作用。該基因編碼一種與表皮生長因子受體（EGFR）和腎上腺素受體相互作用的生長因子受體結合蛋白該蛋白通過與粘著斑激酶（FAK）結合在整合素信號通路和細胞遷移中發揮作用已經發現了編碼兩種不同亞型的轉錄變體[由RefSeq
GRB7基因編碼功能及結構描述
這個基因的產物屬于一個小的轉接器蛋白家族，已知它與許多受體酪氨酸激酶和信號分子相互作用。該基因編碼一種與表皮生長因子受體（EGFR）和腎上腺素受體相互作用的生長因子受體結合蛋白該蛋白通過與粘著斑激酶（FAK）結合在整合素信號通路和細胞遷移中發揮作用已經發現了編碼兩種不同亞型的轉錄變體[由RefSeq
GPB7基因突變與藥物因子介紹
這個基因的產物屬于一個小的轉接器蛋白家族，已知它與許多受體酪氨酸激酶和信號分子相互作用。該基因編碼一種與表皮生長因子受體（EGFR）和腎上腺素受體相互作用的生長因子受體結合蛋白該蛋白通過與粘著斑激酶（FAK）結合在整合素信號通路和細胞遷移中發揮作用已經發現了編碼兩種不同亞型的轉錄變體[由RefSeq
Role－of－ERBB2－in－Signal－Transduction－and－Oncology
Her2 or ERBB2 belongs to a class of proteins having high homology with epidermal growth factor receptor (EGFR or ERBB1). It encodes a protein with the
EGF－Signaling－Pathway
The epidermal growth factor (EGF) peptide induces cellular proliferation through the EGF receptor, which has a tyrosine kinase cytoplasmic domain, a s
VEGF,－Hypoxia,－and－Angiogenesis
Vascular endothelial growth factor (VEGF) plays a key role in physiological blood vessel formation and pathological angiogenesis such as tumor growth
Multiple－antiapoptotic－pathways－from－IGF1R－signaling－lead－to－BAD－phosphory
IGF-1R, the type 1 receptor for insulin-like growth factor, mediates cell survival and growth in response to its ligands IGF-1 and IGF-2. This tyrosin
Role－of－Erk5－in－Neuronal－Survival
Axons extend significant distances to innervate target tissues. At the site of innervation, target tissues release neurotrophins including NGF, BDNF a
GIGYF1基因突變與藥物因子介紹
這個基因編碼銜接蛋白gyf家族的一個成員編碼蛋白包含一個gyf蛋白相互作用域。它結合生長因子受體結合蛋白10，另一種結合激活的胰島素樣生長因子1和胰島素受體并調節受體信號的銜接蛋白[由RefSeq提供，2017年4月]This gene encodes a member of the gyf fam
GIGYF1基因編碼功能及結構描述
這個基因編碼銜接蛋白gyf家族的一個成員編碼蛋白包含一個gyf蛋白相互作用域。它結合生長因子受體結合蛋白10，另一種結合激活的胰島素樣生長因子1和胰島素受體并調節受體信號的銜接蛋白[由RefSeq提供，2017年4月]This gene encodes a member of the gyf fam