Hypoxiaandp53intheCardiovascularsystem
Hypoxic stress, like DNA damage, induces p53 protein accumulation and p53-dependent apoptosis in oncogenically transformed cells. Unlike DNA damage, hypoxia does not induce p53-dependent cell cycle arrest, suggesting that p53 activity is differentially regulated by these two stresses. Hypoxia induces p53 protein accumulation, but in contrast to DNA damage, hypoxia fails to induce endogenous downstream p53 effector mR......閱讀全文
Hypoxia-and-p53-in-the-Cardiovascular-system
Hypoxic stress, like DNA damage, induces p53 protein accumulation and p53-dependent apoptosis in oncogenically transformed cells. Unlike DNA damage, h
HypoxiaInducible-Factor-in-the-Cardiovascular-System
Hypoxia (or low O2 levels) affects various pathologies. First, tissue ischemia, a variation in O2 tension caused by hypoxia/reoxygenation, can lead to
VEGF,-Hypoxia,-and-Angiogenesis
Vascular endothelial growth factor (VEGF) plays a key role in physiological blood vessel formation and pathological angiogenesis such as tumor growth
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p53是一種腫瘤抑制基因(tumor suppressor gene)。在所有惡性腫瘤中,50%以上會出現該基因的突變。由這種基因編碼的蛋白質(protein)是一種轉錄因子(transcriptional factor),其控制著細胞周期的啟動。許多有關細胞健康的信號向p53蛋白發送。關于是否
什么是P53蛋白
p53基因是一種抑癌基因,定位于人類染色體17p13.1,編碼393個氨基酸組成的53kD的核內磷酸化蛋白,被稱為p53蛋白。p53基因是細胞生長周期中的負調節因子,與細胞周期的調控、DNA修復、細胞分化、細胞凋亡等重要的生物學功能有關。p53基因分為野生型和突變型兩種,其產物也有野生型和突變型
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